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Article

Global ablation of the mouse Rab11a gene impairs early embryogenesis and matrix metalloproteinase secretion.

The Journal of biological chemistry - 14 Nov 2014

Yu Shiyan, Yehia Ghassan, Wang Juanfei, Stypulkowski Ewa, Sakamori Ryotaro, Jiang Ping, Hernandez-Enriquez Berenice, Tran Tracy S, Bonder Edward M, Guo Wei, Gao Nan

Abstract excerpt

Rab11a has been conceived as a prominent regulatory component of the recycling endosome, which acts as a nexus in the endo- and exocytotic networks. The precise in vivo role of Rab11a in mouse embryonic development is unknown. We globally ablated Rab11a and examined the phenotypic and molecular outcomes in Rab11a(null) blastocysts and mouse embryonic fibroblasts. Using multiple trafficking assays and...

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Identifiers

PMID: 25271168
DOI: 10.1074/jbc.M113.538223
PMCID: PMC4231680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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