Article
High level isoniazid resistance correlates with multiple mutation in the katG encoding catalase proxidase of pulmonary tuberculosis isolates from the frontier localities of Iran.
Tuberkuloz ve toraks - 1 Jan 2011
Bostanabad Saeed Z, Nojoumi Seyed Ali, Jabbarzadeh Esmaeil, Shekarabei Mehdi, Hoseinaei Hassan, Rahimi Mohammad K, Ghalami Mostafa, Pourazar Dizji Shahin, Sagalchyk Evgeni R, Titov Leonid P
Abstract excerpt
The aim of this study was to investigate the significance of multiple-mutations in the katG gene, predominant nucleotide changes and its correlation with high level of resistance to isoniazid in Mycobacterium tuberculosis isolates that were randomly collected from sputa of 42 patients with primary and secondary active pulmonary tuberculosis from different geographic regions of Iran. Drug susceptibility testing...
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