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Article

Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma

1 Aug 2009

Abstract excerpt

We studied expression of the Aurora A gene and its clinical significance in a cohort of neuroblastoma patients. In addition, we investigated the antitumor activity of MLN8054, a novel small-molecule inhibitor of Aurora A kinase, on cultured NB cell lines in vitro. Aurora A mRNA expression was assessed by quantitative real-time PCR in tumor tissue specimens from 67 patients at diagnosis and in 9 human...

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PMID: 19671766
DOI: 10.1158/1535-7163.mct-08-0857

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