Article
HIV-2 X4 tropism is associated with lower CD4+ cell count in treatment-experienced patients.
AIDS (London, England) - 10 Sept 2014
Visseaux Benoit, Charpentier Charlotte, Rouard Caroline, Fagard Catherine, Glohi David, Tubiana Roland, Damond Florence, Brun-Vézinet Françoise, Matheron Sophie, Descamps Diane
Abstract excerpt
The distribution and evolution of X4/R5 viral tropism during HIV-2 infection remains unknown. HIV-2 tropism was assessed in 83 antiretroviral-experienced patients with virological failure. Tropism was predicted as X4 in 58% of patients and was associated with a CD4 cell count of less than 100 cells/μl, and with a higher number of drug resistance mutations. This high prevalence of X4 virus might compromise the use...
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