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Article

Genotypic HIV-1 tropism determination might help to identify people with exhausted treatment options and advanced disease.

The Journal of antimicrobial chemotherapy - 12 Nov 2021

Bouba Yagai, Armenia Daniele, Forbici Federica, Bertoli Ada, Borghi Vanni, Gagliardini Roberta, Vergori Alessandra, Cicalini Stefania, Mazzotta Valentina, Malagnino Vincenzo, Lichtner Miriam, Latini Alessandra, Mussini Cristina, Andreoni Massimo, Antinori Andrea, Perno Carlo Federico, Ceccherini-Silberstein Francesca, Santoro Maria Mercedes

Abstract excerpt

OBJECTIVES: To evaluate HIV-1 tropism in 1382 combined antiretroviral therapy (cART)-experienced patients failing therapy to characterize those with exhausted therapeutic options. METHODS: HIV-1 genotypic tropism was inferred through Geno2Pheno by estimating the false-positive-rate (FPR) values. Cumulative resistance and drug activity were evaluated by Stanford algorithm. RESULTS: Overall, median (IQR) CD4 count...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34529797
DOI: 10.1093/jac/dkab322

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