Article
Knockdown of Foxg1 in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle.
Aging - 24 Oct 2020
Zhang Yuan, Zhang Shasha, Zhang Zhonghong, Dong Ying, Ma Xiangyu, Qiang Ruiying, Chen Yin, Gao Xia, Zhao Chunjie, Chen Fangyi, He Shuangba, Chai Renjie
Abstract excerpt
Foxg1 plays important roles in regeneration of hair cell (HC) in the cochlea of neonatal mouse. Here, we used Sox9-CreER to knock down Foxg1 in supporting cells (SCs) in the utricle in order to investigate the role of Foxg1 in HC regeneration in the utricle. We found Sox9 an ideal marker of utricle SCs and bred Sox9CreER/+Foxg1loxp/loxp mice to conditionally knock down Foxg1 in utricular SCs. Conditional...
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