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Article

Dendritic cells require the NF-kappaB2 pathway for cross-presentation of soluble antigens.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008

Lind Evan F, Ahonen Cory L, Wasiuk Anna, Kosaka Yoko, Becher Burkhard, Bennett Kathy A, Noelle Randolph J

Abstract excerpt

NF-kappaB-inducing kinase (NIK) is responsible for activation of the non-canonical p100 processing pathway of NF-kappaB activation. This kinase has been shown to be critical for activation of this pathway after signaling through several TNF family members including CD40. The functional importance of this pathway in CD40 and TLR-induced dendritic cell (DC) differentiation was studied in vivo in the alymphoplasia...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18566401
DOI: 10.4049/jimmunol.181.1.354

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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