Cell-intrinsic role for NF-kappa B-inducing kinase in peripheral maintenance but not thymic development of Foxp3+ regulatory T cells in mice.

doi:10.1371/journal.pone.0076216

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Article

Cell-intrinsic role for NF-kappa B-inducing kinase in peripheral maintenance but not thymic development of Foxp3+ regulatory T cells in mice.

PloS one - 1 Jan 2013

Murray Susan E

Abstract excerpt

NF-κB inducing kinase (NIK, MAP3K14) is a key signaling molecule in non-canonical NF-κB activation, and NIK deficient mice have been instrumental in deciphering the immunologic role of this pathway. Global ablation of NIK prevents lymph node development, impairs thymic stromal development, and drastically reduces B cells. Despite altered thymic selection, T cell numbers are near normal in NIK deficient mice. The...

Topics

Animals
Bone Marrow
CD4-Positive T-Lymphocytes
Cell Differentiation
DNA-Binding Proteins
Forkhead Transcription Factors
Immunologic Memory
Mice
Mice, Knockout
Molecular Sequence Data
NF-kappa B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Phenotype

Protein Serine-Threonine Kinases

Signal Transduction

T-Lymphocytes, Regulatory

Thymus Gland

Ubiquitin-Protein Ligases

Source

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Identifiers

PMID: 24073289
DOI: 10.1371/journal.pone.0076216
PMCID: PMC3779168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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