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Article

Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice.

Carcinogenesis - 1 Jun 2010

Davari Parastoo, Hebert Jennifer L, Albertson Donna G, Huey Bing, Roy Ritu, Mancianti Maria L, Horvai Andrew E, McDaniel Lisa D, Schultz Roger A, Epstein Ervin H

Abstract excerpt

Basal cell carcinomas (BCCs) have relative genomic stability and relatively benign clinical behavior but whether these two are related causally is unknown. To investigate the effects of introducing genomic instability into murine BCCs, we have compared ionizing radiation-induced tumorigenesis in Ptch1(+/-) mice versus that in Ptch1(+/-) mice carrying mutant Blm alleles. We found that BCCs in Ptch1(+/-)...

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Source

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Identifiers

PMID: 19995795
DOI: 10.1093/carcin/bgp309
PMCID: PMC2878356

Genes

PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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