Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4⁺T Cells<i>In Vitro</i>

Abstract excerpt

UNLABELLED: The latent HIV-1 reservoir primarily resides in resting CD4(+) T cells which are a heterogeneous population composed of both naive (TN) and memory cells. In HIV-1-infected individuals, viral DNA has been detected in both naive and memory CD4(+) T cell subsets although the frequency of HIV-1 DNA is typically higher in memory cells, particularly in the central memory (TCM) cell subset. TN and TCM cells...

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