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Article

Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL.

Neurobiology of disease - 1 Jan 2015

Liu Xiao-Yun, Gonzalez-Toledo Maria E, Fagan Austin, Duan Wei-Ming, Liu Yanying, Zhang Siyuan, Li Bin, Piao Chun-Shu, Nelson Lila, Zhao Li-Ru

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a Notch3 dominant mutation-induced cerebral small vascular disease, is characterized by progressive degeneration of vascular smooth muscle cells (vSMCs) of small arteries in the brain, leading to recurrent ischemic stroke, vascular dementia and death. To date, no treatment can stop or delay the progression of...

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Source

Identifiers

PMID: 25251607
DOI: 10.1016/j.nbd.2014.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL.PMID 25251607Read ↗

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Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor.Semantic proximity Read ↗

Pathogenesis of CADASIL: transgenic and knock-out mice to probe function and dysfunction of the mutated gene, Notch3, in the cerebrovasculature.Semantic proximity Read ↗

CADASILSemantic proximity Read ↗

Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures.Semantic proximity Read ↗

NOTCH3 R545C mutation drives vascular-neuronal dysfunction and cognitive impairment in CADASIL pathogenesis.Semantic proximity Read ↗

Notch3 Signaling and Aggregation as Targets for the Treatment of CADASIL and Other NOTCH3-Associated Small-Vessel Diseases.Semantic proximity Read ↗

Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cellsSemantic proximity Read ↗

Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis.Semantic proximity Read ↗

Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease.Semantic proximity Read ↗

Cellular and Molecular Characterization of CADASIL Using In Vitro Models of Vascular Smooth Muscle Cells and Blood Vessel OrganoidsSemantic proximity Read ↗

Selective vulnerability of cerebral vasculature to <i>NOTCH3</i> variants in small vessel disease and rescue by phosphodiesterase-5 inhibitorSemantic proximity Read ↗

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