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Directed Differentiation of Embryonic Stem Cells Using a Bead-Based Combinatorial Screening Method

24 Sept 2014

Abstract excerpt

We have developed a rapid, bead-based combinatorial screening method to determine optimal combinations of variables that direct stem cell differentiation to produce known or novel cell types having pre-determined characteristics. Here we describe three experiments comprising stepwise exposure of mouse or human embryonic cells to 10,000 combinations of serum-free differentiation media, through which we discovered...

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PMID: 25251366
DOI: 10.1371/journal.pone.0104301

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