Article

Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in Atypical Teratoid/Rhabdoid Tumors

2023-09-05

Abstract excerpt

<h4>Background</h4> Atypical Teratoid/Rhabdoid Tumors (ATRT) are highly malignant embryonal tumors of the central nervous system with a dismal prognosis. Despite recent advances in understanding the molecular characteristics and subclasses of these tumors, effective therapeutic options remain scarce. <h4>Methods</h4> In this study, we developed and validated a novel patient-derived ATRT culture and xenograft mod...

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Literature Corpus work: aa1f087a-302e-545b-9da1-81b571f2009e
DOI: 10.1101/2023.09.02.556021

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