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Article

Differential MicroRNA-34a Expression and Tumor Suppressor Function in Retinoblastoma Cells

23 Sept 2009

Abstract excerpt

PURPOSE: The role of miR-34a, a p53-regulated microRNA, in retinoblastoma (RB) was investigated. METHODS: The expression of miR-34 family members in RB cells was determined by semiquantitative RT-PCR and real-time qPCR. Regulation of miR-34a expression by p53-activating compounds was determined by qPCR analysis. The tumor suppressor functions of miR-34a in RB cell lines were determined by tetrazolium-based cell...

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PMID: 19443717
DOI: 10.1167/iovs.09-3520

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