Article
Candidate pathway-based genome-wide association studies identify novel associations of genomic variants in the complement system associated with coronary artery disease.
Circulation. Cardiovascular genetics - 1 Dec 2014
Xu Chengqi, Yang Qin, Xiong Hongbo, Wang Longfei, Cai Jianping, Wang Fan, Li Sisi, Chen Jing, Wang Chuchu, Wang Dan, Xiong Xin, Wang Pengyun, Zhao Yuanyuan, Wang Xiaojing, Huang Yufeng, Chen Shanshan, Yin Dan, Li Xiuchun, Liu Ying, Liu Jinqiu, Wang Jingjing, Li Hui, Ke Tie, Ren Xiang, Wu Yanxia, Wu Gang, Wan Jing, Zhang Rongfeng, Wu Tangchun, Wang Junhan, Xia Yunlong, Yang Yanzong, Cheng Xiang, Liao Yuhua, Chen Qiuyun, Zhou Yanhong, He Qing, Tu Xin, Wang Qing K
Abstract excerpt
BACKGROUND: Genomic variants identified by genome-wide association studies (GWAS) explain <20% of heritability of coronary artery disease (CAD), thus many risk variants remain missing for CAD. Identification of new variants may unravel new biological pathways and genetic mechanisms for CAD. To identify new variants associated with CAD, we developed a candidate pathway-based GWAS by integrating expression...
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