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Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization

22 Nov 2021

Abstract excerpt

Abstract BCAT2-mediated branched-chain amino acid (BCAA) catabolism is critical for pancreatic ductal adenocarcinoma (PDAC) development, especially at an early stage. However, whether a high-BCAA diet promotes PDAC development in vivo, and the underlying mechanism of BCAT2 upregulation, remain undefined. Here, we find that a high-BCAA diet promotes pancreatic intraepithelial neoplasia (PanIN) progression in...

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PMID: 35663242
DOI: 10.1093/nsr/nwab212

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