Article
Changes of KRAS Exon 2 Codon 12/13 Mutation Status in Recurrent Colorectal Cancer.
Pathology oncology research : POR - 1 Apr 2015
Dócs Ottó, Fazakas Ferenc, Horváth Nóra Lugosiné, Tóth László, András Csilla, Horváth Zsolt, Méhes Gábor
Abstract excerpt
Colorectal cancer (CRC) is a heterogeneous disease presenting with a wide spectrum of morphological and molecular characteristics sometimes even within the same patient. To understand the mechanisms of oscillations in the KRAS status we evaluated the collective of CRC patients tested using allele-specific PCR and Sanger-sequencing. Mutant KRAS allele was observed in 43.3% of cases. Repeated analysis of KRAS...
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