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Article

Chromatin decondensation and T cell hyperresponsiveness in diabetes-associated hyperglycemia.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014

Martinez Nuria, Vallerskog Therese, West Kim, Nunes-Alves Claudio, Lee Jinhee, Martens Gregory W, Behar Samuel M, Kornfeld Hardy

Abstract excerpt

Diabetes is linked to increased inflammation and susceptibility to certain infectious diseases including tuberculosis (TB). We previously reported that aerosol TB in mice with chronic (≥ 12 wk) hyperglycemia features increased bacterial load, overproduction of several cytokines, and increased immune pathology compared with normoglycemic controls. A similar phenotype exists in human patients with diabetes with TB....

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Identifiers

PMID: 25246495
DOI: 10.4049/jimmunol.1401125
PMCID: PMC4242014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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