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Article

Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.

Biochemistry - 10 Feb 2015

Aldred Katie J, Schwanz Heidi A, Li Gangqin, Williamson Benjamin H, McPherson Sylvia A, Turnbough Charles L, Kerns Robert J, Osheroff Neil

Abstract excerpt

CP-115,955 is a quinolone with a 4-hydroxyphenyl at C7 that displays high activity against both bacterial and human type II topoisomerases. To determine the basis for quinolone cross-reactivity between bacterial and human enzymes, the activity of CP-115,955 and a series of related quinolones and quinazolinediones against Bacillus anthracis topoisomerase IV and human topoisomerase IIα was analyzed. Results...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Topoisomerase IV

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Source

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Identifiers

PMID: 25586498
DOI: 10.1021/bi501073v
PMCID: PMC4427193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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