Article
Type II topoisomerase mutations in Bacillus anthracis associated with high-level fluoroquinolone resistance.
The Journal of antimicrobial chemotherapy - 1 Jul 2004
Bast Darrin J, Athamna Abed, Duncan Carla L, de Azavedo Joyce C S, Low Donald E, Rahav Galia, Farrell David, Rubinstein Ethan
Abstract excerpt
OBJECTIVES: To identify and characterize the mechanisms of high-level fluoroquinolone resistance in two strains of Bacillus anthracis following serial passage in increasing concentrations of fluoroquinolones. METHODS: Fluoroquinolone-resistant isolates of the Sterne and Russian Anthrax Vaccine STi strains were obtained following serial passage in the presence of increasing concentrations of four different...
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