Article
Path of differentiation defines human macrophage identity
2025-01-24
Abstract excerpt
<h4>SUMMARY</h4> Macrophages play central roles in immunity, wound healing, and homeostasis - a functional diversity that is underpinned by varying developmental origins. The impact of ontogeny on properties of human macrophages is inadequately understood. We demonstrate that definitive human fetal liver (HFL) hematopoietic stem cells (HSCs) possess two divergent paths of macrophage specification that lead to dis...
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Identifiers and source
- Literature Corpus work
- 13e4d7c2-1938-5c7f-8f9c-ad5b692190f1
- DOI
- 10.1101/2025.01.24.634694