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Article

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF.

The Journal of experimental medicine - 23 Sept 2013

Guilliams Martin, De Kleer Ismé, Henri Sandrine, Post Sijranke, Vanhoutte Leen, De Prijck Sofie, Deswarte Kim, Malissen Bernard, Hammad Hamida, Lambrecht Bart N

Abstract excerpt

Tissue-resident macrophages can develop from circulating adult monocytes or from primitive yolk sac-derived macrophages. The precise ontogeny of alveolar macrophages (AMFs) is unknown. By performing BrdU labeling and parabiosis experiments in adult mice, we found that circulating monocytes contributed minimally to the steady-state AMF pool. Mature AMFs were undetectable before birth and only fully colonized the...

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Identifiers

PMID: 24043763
DOI: 10.1084/jem.20131199
PMCID: PMC3782041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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