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Article

How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns

21 Nov 2011

Abstract excerpt

Essential roles of NRP1 (neuropilin-1) in cardiovascular development and in neuronal axon targeting during embryogenesis are thought to be mediated primarily through binding of NRP1 to two unrelated types of ligands: the VEGF (vascular endothelial growth factor) family of angiogenic cytokines in the endothelium, and the class 3 semaphorins in neurons. A widely accepted mechanism for the role of NRP1 in the...

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PMID: 22103491
DOI: 10.1042/bst20110697

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