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Article

Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.

Cancer cell - 13 Oct 2014

Schneider Rebekka K, Ademà Vera, Heckl Dirk, Järås Marcus, Mallo Mar, Lord Allegra M, Chu Lisa P, McConkey Marie E, Kramann Rafael, Mullally Ann, Bejar Rafael, Solé Francesc, Ebert Benjamin L

Abstract excerpt

The casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the common deleted region for del(5q) myelodysplastic syndrome (MDS). We generated a murine model with conditional inactivation of Csnk1a1 and found that Csnk1a1 haploinsufficiency induces hematopoietic stem cell expansion and a competitive repopulation advantage, whereas homozygous deletion induces hematopoietic stem cell...

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Identifiers

PMID: 25242043
DOI: 10.1016/j.ccr.2014.08.001
PMCID: PMC4199102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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