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Article

CSNK1A1 mutations and isolated del(5q) abnormality in myelodysplastic syndrome: a retrospective mutational analysis.

The Lancet. Haematology - 1 May 2015

Smith Alexander E, Kulasekararaj Austin G, Jiang Jie, Mian Syed, Mohamedali Azim, Gaken Joop, Ireland Robin, Czepulkowski Barbara, Best Steven, Mufti Ghulam J

Abstract excerpt

BACKGROUND: A mechanism for clonal growth advantage in isolated del(5q) disease remains elusive. CSNK1A1 resides on the critically deleted region, and deletion of this gene has been shown in mouse knockout and transplantation studies to produce some characteristics of bone marrow failure, including a proliferative advantage. We aimed to establish the frequency, nature, and clinical association of CSNK1A1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26688096
DOI: 10.1016/S2352-3026(15)00050-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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