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Gene expression profiling of CD34<sup>+</sup> cells in patients with the 5q− syndrome

3 Oct 2007

Abstract excerpt

The transcriptome of the CD34+ cells was determined in a group of 10 patients with the 5q- syndrome using a comprehensive array platform, and was compared with the transcriptome of CD34+ cells from 16 healthy control subjects and 14 patients with refractory anaemia and a normal karyotype. The majority of the genes assigned to the commonly deleted region (CDR) of the 5q- syndrome at 5q31-q32 showed a reduction in...

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PMID: 17916100
DOI: 10.1111/j.1365-2141.2007.06833.x

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