Article

Haploinsufficiency of miR-143 and miR-145 reveal targetable dependencies in resistant del(5q) myelodysplastic syndrome

2024-05-15

Abstract excerpt

<title>Abstract</title> <p>Myelodysplastic syndromes (MDS) are stem cell disorders characterized by ineffective hematopoiesis and risk of transformation to acute myeloid leukemia (AML). Chromosomal alterations are frequent in MDS, with interstitial deletion of chromosome 5q (del(5q)) being the most common. Lenalidomide is the current first-line treatment for del(5q) MDS and its efficacy relies on degradation of C...

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Literature Corpus work: b8502a5c-c125-580f-8043-0547cb82b865
DOI: 10.21203/rs.3.rs-4339623/v1

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