A precision medicine approach to the myelodysplastic syndrome with isolated deletion 5q, 50 years after its discovery

Abstract excerpt

ABSTRACT: In 1974, Van den Berghe et al described a distinct hematologic disorder associated with acquired, interstitial deletion of part of the long arm of chromosome 5. This condition is now classified as myelodysplastic syndrome (MDS) with isolated deletion 5q, or MDS-del(5q). The common deletion region 5q32-5q33 contains several genes and microRNAs whose expression levels are reduced in hematopoietic cells,...

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