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Article

TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.

Molecular oncology - 1 Dec 2020

Maddalena Francesca, Condelli Valentina, Matassa Danilo Swann, Pacelli Consiglia, Scrima Rosella, Lettini Giacomo, Li Bergolis Valeria, Pietrafesa Michele, Crispo Fabiana, Piscazzi Annamaria, Storto Giovanni, Capitanio Nazzareno, Esposito Franca, Landriscina Matteo

Abstract excerpt

Metabolic rewiring is a mechanism of adaptation to unfavorable environmental conditions and tumor progression. TRAP1 is an HSP90 molecular chaperone upregulated in human colorectal carcinomas (CRCs) and responsible for downregulation of oxidative phosphorylation (OXPHOS) and adaptation to metabolic stress. The mechanism by which TRAP1 regulates glycolytic metabolism and the relevance of this regulation in...

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Identifiers

PMID: 33025742
DOI: 10.1002/1878-0261.12814
PMCID: PMC7718945

Genes

TRAP1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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