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Article

TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma.

Cell death and differentiation - 1 Nov 2016

Lettini Giacomo, Sisinni Lorenza, Condelli Valentina, Matassa Danilo Swann, Simeon Vittorio, Maddalena Francesca, Gemei Marica, Lopes Elvira, Vita Giulia, Del Vecchio Luigi, Esposito Franca, Landriscina Matteo

Abstract excerpt

Colorectal carcinoma (CRC) is a common cause of cancer-related death worldwide. Indeed, treatment failures are triggered by cancer stem cells (CSCs) that give rise to tumor repopulation upon initial remission. Thus, the role of the heat shock protein TRAP1 in stemness was investigated in CRC cell lines and human specimens, based on its involvement in colorectal carcinogenesis, through regulation of apoptosis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27662365
DOI: 10.1038/cdd.2016.67
PMCID: PMC5071570

Genes

TRAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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