Article

Comprehensive pan-cancer analysis and experimental validation of TRAP1 as a possible medicinal target

2025-09-22

Abstract excerpt

<title>Abstract</title> <p>Purpose Tumor necrosis factor receptor-associated protein 1 (TRAP1) is essential for carcinogenesis and the advancement of cancer, making it a promising therapeutic target in oncology. Nevertheless, comprehensive bioinformatic analyses of TRAP1 across diverse cancer types are limited. Herein, we analyzed TRAP1 across all cancer types, focusing on its expression in relation to prognosis,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77c2ce93-8227-5168-8a42-df79ef2e5a1d
DOI: 10.21203/rs.3.rs-7381783/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comprehensive pan-cancer analysis and experimental validation of TRAP1 as a possible medicinal targetDOI 10.21203/rs.3.rs-7381783/v1Read

TRAP1 controls the crosstalk between SDHA/HIF-1α, HIF/ERK1/2/Twist, and HIF/FoxC/Twist pathways via HIF-1α during EMT in colorectal cancerSemantic proximity Read

Pan-cancer analysis reveals that TK1 promotes tumor progression by mediating cell proliferation and Th2 cell polarizationSemantic proximity Read

Establishment of a neutrophil extracellular trap-related prognostic signature for colorectal cancer liver metastasis and expression validation of CYP4F3Semantic proximity Read

TMUB1 as a diagnostic and prognostic marker for colorectal cancerSemantic proximity Read

TPI1 promotes tumor progression and M2 macrophage polarization: Integrated pan-cancer and lung adenocarcinoma insights.Semantic proximity Read

TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivationSemantic proximity Read

PTOV1 Exerts Pro-oncogenic Role in Colorectal Cancer by Modulating SQSTM1-Mediated Autophagic Degradation of p53Semantic proximity Read

TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.Semantic proximity Read

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.Semantic proximity Read

Role of autophagy-related genes in liver cancer prognosisSemantic proximity Read

Multi-omics Analysis and Functional Characterization of the TIMP1 in Colorectal CancerSemantic proximity Read

PAMR1 is a favorable diagnostic and prognostic biomarker in hepatocellular carcinomaSemantic proximity Read