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Article

Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism.

Mitochondrion - 1 Jan 2020

Ramkumar Balaji, Dharaskar Shrikant P, Mounika Guntipally, Paithankar Khanderao, Sreedhar Amere Subbarao

Abstract excerpt

The stress response forms the most ancient defense system in living cells. Heat shock proteins (Hsps) are highly conserved across species and play major roles in mounting the stress response. The emerging information now suggests that Hsp90 family of chaperones display additional cellular roles contributing to diseases like cancer. For this reason, pharmacological targeting of Hsp90 has emerged as a novel...

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Identifiers

PMID: 31669620
DOI: 10.1016/j.mito.2019.09.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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