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Article

TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells.

Cancer letters - 28 Jun 2009

Costantino Eleonora, Maddalena Francesca, Calise Serena, Piscazzi Annamaria, Tirino Virginia, Fersini Alberto, Ambrosi Antonio, Neri Vincenzo, Esposito Franca, Landriscina Matteo

Abstract excerpt

TRAP1 is a component of a pro-survival mitochondrial pathway up-regulated in tumor cells. The evaluation of TRAP1 expression in 26 human colorectal carcinomas showed up-regulation in 17/26 tumors. Accordingly, TRAP1 levels were increased in HT-29 colorectal carcinoma cells resistant to 5-fluorour...

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Source

Identifiers

PMID: 19217207
DOI: 10.1016/j.canlet.2009.01.018

Genes

TRAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19217207-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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