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Article

Ground state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymes.

PLoS biology - 1 Jul 2013

Andrews Logan D, Fenn Tim D, Herschlag Daniel

Abstract excerpt

Enzymes stabilize transition states of reactions while limiting binding to ground states, as is generally required for any catalyst. Alkaline Phosphatase (AP) and other nonspecific phosphatases are some of Nature's most impressive catalysts, achieving preferential transition state over ground state stabilization of more than 10²²-fold while utilizing interactions with only the five atoms attached to the...

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PMID: 23843744
DOI: 10.1371/journal.pbio.1001599
PMCID: PMC3699461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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