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Article

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.

Nature chemical biology - 27 Nov 2011

Wang Huanchen, Falck J R, Hall Traci M Tanaka, Shears Stephen B

Abstract excerpt

Inositol pyrophosphates (such as IP7 and IP8) are multifunctional signaling molecules that regulate diverse cellular activities. Inositol pyrophosphates have 'high-energy' phosphoanhydride bonds, so their enzymatic synthesis requires that a substantial energy barrier to the transition state be overcome. Additionally, inositol pyrophosphate kinases can show stringent ligand specificity, despite the need to...

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Identifiers

PMID: 22119861
DOI: 10.1038/nchembio.733
PMCID: PMC3923263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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