Article
SNP-guided identification of monoallelic DNA-methylation events from enrichment-based sequencing data.
Nucleic acids research - 10 Nov 2014
Steyaert Sandra, Van Criekinge Wim, De Paepe Ayla, Denil Simon, Mensaert Klaas, Vandepitte Katrien, Vanden Berghe Wim, Trooskens Geert, De Meyer Tim
Abstract excerpt
Monoallelic gene expression is typically initiated early in the development of an organism. Dysregulation of monoallelic gene expression has already been linked to several non-Mendelian inherited genetic disorders. In humans, DNA-methylation is deemed to be an important regulator of monoallelic gene expression, but only few examples are known. One important reason is that current, cost-affordable truly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.