Article
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
Diabetes - 1 Apr 2009
Friedman David J, Talbert Matthew E, Bowden Donald W, Freedman Barry I, Mukanya Yves, Enjyoji Keiichi, Robson Simon C
Abstract excerpt
OBJECTIVE: The vascular ectonucleotidase ENTPD1 protects against renal injury and modulates glucose homeostasis in mouse models. We sought to determine whether human variation in ENTPD1 influences predisposition to diabetes or diabetic nephropathy. RESEARCH DESIGN AND METHODS: We analyzed ENTPD1 single nucleotide polymorphisms (SNPs) in 363 African American control subjects, 380 subjects with type 2 diabetes and...
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