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Article

Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2014

Martinez M Elena, Charalambous Marika, Saferali Aabida, Fiering Steven, Naumova Anna K, St Germain Donald, Ferguson-Smith Anne C, Hernandez Arturo

Abstract excerpt

The Dio3 gene, which encodes for the type 3 deiodinase (D3), controls thyroid hormone (TH) availability. The lack of D3 in mice results in tissue overexposure to TH and a broad neuroendocrine phenotype. Dio3 is an imprinted gene, preferentially expressed from the paternally inherited allele in the mouse fetus. However, heterozygous mice with paternal inheritance of the inactivating Dio3 mutation exhibit an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25232934
DOI: 10.1210/me.2014-1210
PMCID: PMC4213365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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