Article
Fine-tuning notes in the behavioral symphony: parent-of-origin allelic gene expression in the brain.
Advances in genetics - 1 Jan 2014
Sittig Laura J, Redei Eva E
Abstract excerpt
The gene encoding the thyroid hormone (TH)-metabolizing enzyme, deiodinase type III (Dio3), exhibits a preferential paternal expression in most tissues. Dio3 is part of the Dlk1-Dio3 imprinted locus, so named according to its ancestral genes, Delta-like homolog 1 (Dlk1) and Dio3, which among other important functions control metabolic programming in the developing embryo and fetus. Here, we describe the aspects...
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