Article
The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia.
Experimental hematology - 1 Oct 2016
Aslam Rukhsana, Kapur Rick, Segel George B, Guo Li, Zufferey Anne, Ni Heyu, Semple John W
Abstract excerpt
For many years, splenectomy has been used to treat immune thrombocytopenia (ITP), and this procedure benefits approximately two-thirds of the treated patients. Although splenectomy may raise platelet counts, antibody-coated platelets and cytotoxic T lymphocytes appear to persist or can change over time. To better understand how the spleen may affect anti-platelet immune responses, we used a murine model of ITP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.