Article

Positive Regulation of S-adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation Factors

2023-11-06

Abstract excerpt

S-adenosylmethionine (SAM) is considered to be a useful therapeutic agent for degenerative cartilage diseases, although its mechanism is not clear. We previously found that polyamines stimulate expression of differentiated phenotype of chondrocytes. We also found that cellular communication network factor 2 (CCN2) played a huge role in the proliferation and differentiation of chondrocytes. Therefore, we hypothesiz...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7cccda41-d8ea-5f77-a3f9-b621afec0ccf
DOI: 10.20944/preprints202311.0304.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Positive Regulation of S-adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation FactorsDOI 10.20944/preprints202311.0304.v1Read

Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblastsSemantic proximity Read

Targeting polyamine metabolism for cancer therapy and preventionSemantic proximity Read

Basic Knowledge of Polyamines That Researchers Must Know before Starting Research, and the Relationship of Polyamines to Aging, Health and DiseaseSemantic proximity Read

Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype.Semantic proximity Read

SMOX and SMS Responsible for Polyamine Metabolism Enhanced AdipogenesisSemantic proximity Read

Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways.Semantic proximity Read

A perspective of polyamine metabolismSemantic proximity Read

Polydeoxyribonucleotide ameliorates IL-1β-induced impairment of chondrogenic differentiation in human bone marrow-derived mesenchymal stem cellsSemantic proximity Read

HSG cells differentiated by culture on extracellular matrix involves induction of S-adenosylmethione decarboxylase and ornithine decarboxylase.Semantic proximity Read

Inhibition of Polyamine Uptake Potentiates the Anti-Proliferative Effect of Polyamine Synthesis Inhibition and Preserves the Contractile Phenotype of Vascular Smooth Muscle Cells.Semantic proximity Read

Polyamine Homeostasis in Snyder-Robinson SyndromeSemantic proximity Read

Molecular mechanisms of polyamine analogs in cancer cellsSemantic proximity Read