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Article

Expression and secretion of wild type and mutant GNE proteins in Dictyostelium discoideum.

CNS & neurological disorders drug targets - 1 Jan 2014

Grover Sonam, Aslam Saima, Sharma Vijeta, Arya Ranjana

Abstract excerpt

GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase) is a bifunctional enzyme which catalyzes the conversion of UDP-GlcNAc to ManNAc and ManNAc to ManNAc 6-phosphate, key steps in the sialic acid biosynthesis. Mutations in GNE lead to a neuromuscular disorder, Hereditary Inclusion Body Myopathy (HIBM). A major limitation in understanding the function of GNE is lack of recombinant full length GNE...

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Source

Identifiers

PMID: 25230235
DOI: 10.2174/1871527313666140917094905

Genes

GNE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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