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Article

Aberrant O-GlcNAcylation disrupts GNE enzyme activity in GNE myopathy.

The FEBS journal - 1 Jun 2016

Bennmann Dorit, Weidemann Wenke, Thate Annett, Kreuzmann Denise, Horstkorte Rüdiger

Abstract excerpt

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme for the biosynthesis of sialic acids. Sialic acids are terminal monosaccharides of glycoconjugates and gangliosides, which have an essential influence on various cell interactions. The sialylation of proteins varies during development, aging, and pathogenesis of degenerative diseases such as Morbus Alzheimer, diabetes mellitus...

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Source

Identifiers

PMID: 27037841
DOI: 10.1111/febs.13729

Genes

GNE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aberrant O-GlcNAcylation disrupts GNE enzyme activity in GNE myopathy.PMID 27037841Read ↗

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