Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions.

The Journal of biological chemistry - 9 Jun 2017

Pham Nam D, Pang Poh-Choo, Krishnamurthy Soumya, Wands Amberlyn M, Grassi Paola, Dell Anne, Haslam Stuart M, Kohler Jennifer J

Abstract excerpt

GNE (UDP-GlcNAc 2-epimerase/ManNAc kinase) myopathy is a rare muscle disorder associated with aging and is related to sporadic inclusion body myositis, the most common acquired muscle disease of aging. Although the cause of sporadic inclusion body myositis is unknown, GNE myopathy is associated with mutations in GNE. GNE harbors two enzymatic activities required for biosynthesis of sialic acid in mammalian cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylglucosamine
Share to Carbohydrate Epimerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Cell Membrane

Share to Myositis, Inclusion Body

Share to Polysaccharides

Share to Protein Domains

Share to Sialic Acids

Source

Open in PubMed Open full text

Identifiers

PMID: 28424265
DOI: 10.1074/jbc.M116.764597
PMCID: PMC5465488

Genes

GNE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of altered sialic acid biosynthesis on N-linked glycan branching and cell surface interactions.PMID 28424265Read ↗

Non-specific accumulation of glycosphingolipids in GNE myopathy.Semantic proximity Read ↗

The glycomic sialylation profile of GNE Myopathy muscle cells does not point to consistent hyposialylation of individual glycoconjugates.Semantic proximity Read ↗

Aberrant O-GlcNAcylation disrupts GNE enzyme activity in GNE myopathy.Semantic proximity Read ↗

Evaluation of N-Acetylmannosamine Administration to Restore Sialylation in GNE-Deficient Human Embryonal Kidney CellsSemantic proximity Read ↗

Hypoglycosylation of alpha-dystroglycan in patients with hereditary IBM due to GNE mutations.Semantic proximity Read ↗

GNE Myopathy and Cell Apoptosis: A Comparative Mutation Analysis.Semantic proximity Read ↗

Understanding pathophysiology of GNE myopathy and current progress towards drug development.Semantic proximity Read ↗

Sialic acid deficiency is associated with oxidative stress leading to muscle atrophy and weakness in GNE myopathySemantic proximity Read ↗

Novel GNE mutations in autosomal recessive hereditary inclusion body myopathy patients.Semantic proximity Read ↗

Serum neural cell adhesion molecule is hyposialylated in hereditary inclusion body myopathy.Semantic proximity Read ↗

Role of UDP-N-acetylglucosamine2-epimerase/N-acetylmannosamine kinase (GNE) in β1-integrin-mediated cell adhesion.Semantic proximity Read ↗

Mutation update for GNE gene variants associated with GNE myopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.