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Article

SIRT1 links CIITA deacetylation to MHC II activation

2 Sept 2011

Abstract excerpt

Antigen-dependent stimulation of T cells plays a critical role in adaptive immunity and host defense. Activation of major histocompatibility complex II (MHC II) molecules, dictated by Class II transactivator (CIITA), is considered a pivotal step in this process. The mechanism underlying differential regulation of CIITA activity by the post-translational modification machinery (PTM) and its implications are not...

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PMID: 21890893
DOI: 10.1093/nar/gkr651

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