Article
Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2014
Richardson Tom G, Minica Camelia, Heron Jon, Tavare Jeremy, MacKenzie Alasdair, Day Ian, Lewis Glyn, Hickman Matthew, Vink Jacqueline M, Gelernter Joel, Kranzler Henry R, Farrer Lindsay A, Munafò Marcus, Wynick David
Abstract excerpt
There is a large body of pre-clinical and some clinical data to link the neuropeptide galanin to a range of physiological and pathological functions that include metabolism, depression, and addiction. An enhancer region upstream of the human GAL transcriptional start site has previously been characterised. In-vitro transfection studies in rat hypothalamic neurons demonstrated that the CA allele was 40% less...
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