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Article

Brain galanin system genes interact with life stresses in depression-related phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014

Juhasz Gabriella, Hullam Gabor, Eszlari Nora, Gonda Xenia, Antal Peter, Anderson Ian Muir, Hökfelt Tomas G M, Deakin J F William, Bagdy Gyorgy

Abstract excerpt

Galanin is a stress-inducible neuropeptide and cotransmitter in serotonin and norepinephrine neurons with a possible role in stress-related disorders. Here we report that variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events in...

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Identifiers

PMID: 24706871
DOI: 10.1073/pnas.1403649111
PMCID: PMC4000859

Genes

GAL
GALR1
GALR2
GALR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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