Article
Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014
Hart Amy B, Gamazon Eric R, Engelhardt Barbara E, Sklar Pamela, Kähler Anna K, Hultman Christina M, Sullivan Patrick F, Neale Benjamin M, Faraone Stephen V, de Wit Harriet, Cox Nancy J, Palmer Abraham A
Abstract excerpt
Here, we extended our findings from a genome-wide association study of the euphoric response to d-amphetamine in healthy human volunteers by identifying enrichment between SNPs associated with response to d-amphetamine and SNPs associated with psychiatric disorders. We found that SNPs nominally associated (P ≤ 0.05 and P ≤ 0.01) with schizophrenia and attention deficit hyperactivity disorder were also nominally...
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