Article
BRAF activates and physically interacts with PAK to regulate cell motility.
Endocrine-related cancer - 1 Jan 2014
McCarty Samantha K, Saji Motoyasu, Zhang Xiaoli, Knippler Christina M, Kirschner Lawrence S, Fernandez Soledad, Ringel Matthew D
Abstract excerpt
Increased p21-activated kinase (PAK) signaling and expression have been identified in the invasive fronts of aggressive papillary thyroid cancers (PTCs), including those with RET/PTC, BRAFV600E, and mutant RAS expression. Functionally, thyroid cancer cell motility in vitro is dependent on group 1 PAKs, particularly PAK1. In this study, we hypothesize that BRAF, a central kinase in PTC tumorigenesis and invasion,...
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