Article
Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.
Thyroid : official journal of the American Thyroid Association - 1 Aug 2009
Schweppe Rebecca E, Kerege Anna A, Sharma Vibha, Poczobutt Joanna M, Gutierrez-Hartmann Arthur, Grzywa Rachel L, Haugen Bryan R
Abstract excerpt
BACKGROUND: The mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway plays an important role in papillary and anaplastic thyroid cancer (PTC and ATC) due to activating mutations in BRAF, RAS, or rearrangements in RET/PTC1. The objective of this study was to thoroughly test whether the BRAF V600E mutation predicts response to mitogen-activated protein kinase kinase 1/2...
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